An in-line membrane filter may be used for the intravenous infusion of Vyxeos Liposomal, provided the minimum pore diameter of the filter is greater than or equal to 15 µm.1

  • Remove the vials of Vyxeos Liposomal from the refrigerator
  • Equilibrate at room temperature for 30 minutes
  • Do not heat, vortex, or shake vigorously

  • Reconstitute each vial with 19 mL of sterile water for injection using a sterile syringe
  • Immediately thereafter start a 5 minute timer
  • Carefully swirl the contents of the vial for 5 minutes while gently inverting the vial every 30 seconds

  • After reconstitution, leave to rest for 15 minutes
  • The reconstituted product will be an opaque, purple, homogenous, dispersion, essentially free from particulates

  • Gently invert each vial 5 times prior to withdrawing the reconstituted product for further dilution
  • If the reconstituted product is not diluted into an infusion bag immediately, store in the refrigerator at 2ºC-8ºC for up to 4 hours

  • Aseptically withdraw the calculated volume of reconstituted Vyxeos Liposomal from the vial(s) with a sterile syringe and transfer it to an infusion bag containing 500 mL of 0.9% sodium chloride injection or 5% dextrose injection. There may be residual product remaining in the vial. Discard unused portion
  • Gently invert the bag to mix the solution
  • If the diluted solution is not used immediately, store in the refrigerator at 2ºC-8ºC for up to 4 hours
  • Vyxeos Liposomal should not be mixed with any other medications


  1. Vyxeos Liposomal – Summary of Product Characteristics, October 2019




Reporting of side effects: Adverse events should be reported. Healthcare professionals are asked to report any suspected adverse reactions via their national reporting system. Adverse events should also be reported to Jazz Pharmaceuticals by email: or by fax to +44 (0) 1865 598765


INT-VYX-2000063 | June 2020