Vyxeos
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The formulation

Vyxeos Liposomal is the first dual-drug advanced liposomal formulation1

Optimising the delivery of daunorubicin and cytarabine1,2

the formulation

Mechanism of action

play
the formulation
Synergistic ratio

Synergistic ratio

Fixed 1:5 molar ratio of daunorubicin and cytarabine has been shown to produce a synergistic effect in vitro3

High concentration

High concentration

Liposomes accumulate and persist in the bone marrow in high concentrations, as shown in animal models4

Prolonged delivery

Prolonged delivery

Synergistic molar ratio maintained for a prolonged period of time – over 24 hours after administration1,4

Preferential uptake

Preferential uptake

Vyxeos Liposomal is preferentially taken up by leukaemia cells vs normal bone marrow cells, as shown in vitro2,4

This website is intended for European Healthcare Professionals only.
REFERENCES
  • Tolcher AW, Mayer LD. Future Oncol 2018;14(13):1317-32.
  • Lancet JE et al. J Clin Oncol 2018;36(26):2684-92.
  • Dicko A et al. Expert Opin Drug Deliv 2010;7(12):1329-41.
  • Vyxeos Liposomal. European Summary of Product Characteristics.

ADVERSE EVENTS REPORTING

Adverse events should be reported. Healthcare professionals are asked to report any adverse events via their national reporting system (see Section 4.8 of SmPC). Adverse events should also be reported to Jazz Pharmaceuticals by email to medinfo-int@jazzpharma.com or phone via +353 1 968 1631 (may include an international call charge).

Job code: INT-VYX-2200141
Date of Preparation: September 2022
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Patient information leaflet
EMA - Information on Vyxeos Liposomal

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If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly through your national medicines side effect reporting system or to Jazz Pharmaceuticals AEreporting@jazzpharma.com. By reporting side effects, you can help provide more information on the safety of this medicine.